The Dysport® Difference

The Dysport® difference

Neurotoxins/neuromodulators/wrinkle relaxers are all descriptors for an injectable used to minimize contraction of specifically targeted muscles.

Neurotoxins have been used not only in aesthetics, but in cases of muscle dystonia, Bell’s palsy and migraines.

There are a few key players in the neuromodulator arena. Botox®, Dysport®, Xeomin®, Jeuveau® and the newest to the market, Daxxify®.

The concept remains the same in that they all affect the ability of the injected muscle, to contract. What varies is duration of effect, onset of effect and efficacy of degree of muscle paralysis.

On average, neurotoxins last 3-4 months, with the exception of Daxxify®, which claims a duration of 6-9months and has a mechanism of action slightly different than its predecessors.

Clinically, I have found Dysport® to have the quickest onset and longest duration of effect, of the tox products I have tried, which includes Botox®, Xeomin® and Dysport®. Some attribute the Dysport® difference to the weight of the active protein. Dysport® weighing in at 0.27ng, Botox® at 0.18ng, 0.08ng in Xeomin® , 0.15ng in Jeuveau® (AKA “NEWTOX”) and now Daxxify®, 0.18ng (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316182/).

I have chosen to not bring in Daxxify® into my clinic yet, as I am waiting to see how it does clinically in the US first, currently it appears to be looking a little controversial. The price point would be much higher and I want to see consistency in its promised 6-9month duration, before offering it to my patients.

Something I have seen since 2020, is a decrease in overall efficacy, of some of these neuromodulators. There was a survey in late 2020 I participated in with 1800 providers across 33 countries, where we all reported this efficacy issue. The issues ranged from zero effect to decreased duration of effect of the toxins. More recently in 2022, there was a small study on this same topic and it was determined that an active COVID 19 infection or having been vaccinated and /or boosted, seemed to create a less effective response to our beloved wrinkle relaxers.

This is something that needs more research to determine how long this may occur or if one who has such a response, ever returns to a previously normal response to their tox treatment.

I will say, I have noticed that those who have reported issues with Botox® brand since COVID, have done well with Dysport®, which is why it remains my tox of choice!

Crystal Osborn, PA-C

Owner at Sunkyssed Injector